Chemical process research, development and optimization for scale-up
Having developed several chemical processes for products that are on the market, Provence Technologies can claim real strengthes in this field (visit our news page or click here to read about another success story
) such as synthetic pathways optimization with respect to industrial restrains (raw materials availability, security, cost and environment).
With the recent partnership with Axyntis Group and the in-house set up of a 60L kilolab process optimization is proposed for manufacturing on the kilogram scale and can then be transferred on the ton scale.
In terms of analyses, we house or have access to all necessary equipment to report on LC-MS and NMR analyses, residual solvents, water content, heavy metals content, RX analysis, IR...
Isolation and Characterization of Impurities
According to the type of media in which the impurities have been detected, to their concentrations and according to the requested quantities, Provence Technologies will either proceed with isolation and purification of these impurities or try to enrich them prior to isolation and purification or try to generate more of them via forced degradations or find a chemical pathway to synthesize these impurities.
- reagents, scaffolds and building blocks
- intermediates and advanced intermediates
- lead compounds
- samples and reference compounds
- analytical standards
- focused libraries
Our lab capacity enables us to respond to inquiries dealing with quantities ranging from mg to kg-scale. The scope of our services also includes:
- literature search
- design of new routes of synthesis and process research
- process development and optimization for scale-up
- construction of full technical package for transfer to larger scales
- analytical development
We are accustomed to studying cases involving a large variety of chemistries. We are true generalists in this field yet with special expertises in phenothiazines, azaindoles, sugar, nucleosides, nucleotides, conjugated dienes, heterocyclic chemistries which we have also built through our internal R&D programs